Review & Perspective articles

ALL PUBLICATIONS

2008 2007 2006 2005 2004 2003 2002 2001 2000 1990s

Review & Perspective articles

1. Cho, W. (2000) “Structure and function of group V phospholipase A₂,” Biochim. Biophys. Acta 1488, 48-58.

2. Cho, W. (2001) “Membrane targeting by C1 and C2 domains,” J. Biol. Chem. 276, 32407-32410.

3. Cho, W., Bittova, L., and Stahelin, R. V. (2001) “In vitro Membrane Binding Assays for Peripheral Proteins” Anal. Biochem. 296, 153-161.

4. Cho, W. and Stahelin, R.V. “Membrane-protein interactions in cell signaling and membrane trafficking,” (2005) Ann. Rev. Biophys. Biomol. Struct. 34, 119-151

5. Cho, W. and Stahelin, R.V. “In vitro and cellular membrane binding mechanisms of membrane targeting domains,” (2005) In “Protein-Lipid Interactions”, Tamm, L. K. Ed., Academic Press, N.Y. pp. 369-401

6. Cho, W. (2006) “Building Signaling Complexes at the Membrane” Science STKE 2006, pe7 (2006)

7. Cho, W. (2006) “Real-time fluorescent assays of phospholipases,” (2006) ACS Chem Biol. 1, 65-66

8. Cho, W. (2006) “Special Issue: Lipid-binding domains,” Biochim. Biophys. Acta 1761, 803-804.

9. Cho, W. and Stahelin, R. V. (2006) “Membrane binding and subcellular targeting of C2 domains,” Biochim. Biophys. Acta 1761, 838-849.

ALL PUBLICATIONS (In Reverse Chronological order): Key publications are shown in teal.

<2008>

• Tian, W., Wijewickrama, G. T., Kim, J. H., Das, S., Tun, M. P., Gokhale, N., Jung, J.W., Kim, K. P., and Cho, W. “Mechanism of Regulation of Group IVA Phospholipase A₂ Activity by Ser⁷²⁷ Phosphorylation,” J. Biol. Chem. In press

<2007>

• Kwatia, M.A, Doyle, C.B, Cho, W., Enhorning, G., and Ackerman, S.J (2007) “The Combined Activities of Secretory Phospholipases and Eosinophil Lysophospholipases Induce Pulmonary Surfactant Dysfunction by Phospholipid Hydrolysis,” J. Allergy Clin Immunol 119, 838-847.

• Chaudhari, A., Mahfouz, M., Fialho, A.M., Yamada, T., Granja, A.T., Zhu, Y., Hashimoto, W., Schlarb-Ridley, B., Cho, W., Gupta, T.D., and Chakrabarty, A.M. (2007) “Cupredoxin - Cancer Interrelationship: Azurin Binding with EphB2, Interference in EphB2 Tyrosine Phosphorylation, and Inhibition of Cancer Growth” Biochemistry 46, 1799-1810

• Melowic, H.R., Stahelin, R.V., Blatner, N.R., Tian, W., Hayashi, K., Altman, A., and Cho, W., (2007)  “Mechanism of Diacylglycerol-Induced Membrane Targeting and Activation of Protein Kinase Cθ” J. Biol. Chem. 282, 21467-76

• Lamour, N.F., Stahelin, R.V., Wijesinghe, D.S., Maceyka, M., Wang, E., Allegood, J.C., Cho, W., Merrill, Jr., A.H., and Chalfant, C.E. (2007) “Ceramide kinase utilizes ceramide provided by ceramide transport protein. Localization to subcellular compartments of eicosanoid synthesis” J. Lipid Res. 48, 1293-304

• Stahelin, R.V., Karathanassis, D.,Murray, D., Williams, R.L., Cho, W. (2007) “Structural and Membrane Binding Analysis of the PX Domain of Bem1p: Basis of Phosphatidylinositol-4-Phosphate Specificity” J. Biol. Chem. 282, 25737-25747

• Blatner, N.R., Wilson, M.I. Lei, C., Hong, W., Murray, D., Williams, R.L. and Cho, W. (2007) “The Structural Basis of Novel Endosome Anchoring Activity of KIF16B Kinesin,” EMBO J. 26, 3709-3719

• Stahelin, R.V., Subramanian, P., Vora, M., Cho, W., and Chalfant. C.E., (2007) “Ceramide-1-phosphate binds group IVA cytosolic phospholipase A₂ via a novel site in the C2 domain,” J. Biol. Chem. 282, 20467-74

• Muñoz, N.M., Meliton, A.Y., Arm, J.P., Zhu, X., Bonventre, J.V., Cho, W., and Leff. A.R. (2007) “Deletion of Secretory Group V Phospholipase A₂ Attenuates Cell Migration and Airway Hyperresponsiveness in Immune-Sensitized Mice,” J. Immunol. 179, 4800-4807

• Hom, R., Vora, M., Regner, M., Subach, O.M., Cho, W., Verkhusha, V.V., Stahelin R.V., and Kutateladze, T.G. (2007) “pH-dependent binding of the EHTH domain of epsin and the ANTH domain of AP180 to PI(4,5)P₂-containing bilayers” J. Mol. Biol. 373, 412-23

• Manna, D., Albanese, A., Park, W.S., and Cho, W. (2007) “Mechanistic Basis of Differential Cellular Responses of PtdIns(3,4)P₂- and PtdIns(3,4,5)P₃-Binding PH Domains,” J. Biol. Chem. 282, 32093-32105

• Bhardwaj, N., Stahelin, R.V., Cho, W., Lu, H. (2007) “MeTaDoR: A comprehensive resource for membrane targeting domains and their host proteins,”  Bioinformatics 23, 3110-3112

• Manna, D. and Cho, W. (2007) “Real-Time Cell Assays of Phospholipases A₂ Using Fluorogenic Phospholipids,” Methods Enzymol. 434, 15-27

<2006>

• Cho, W. (2006) “Building Signaling Complexes at the Membrane” Science STKE 2006, pe7 (2006)

• Cho, W. (2006) “Real-time fluorescent assays of phospholipases,” (2006) ACS Chem Biol. 1, 65-66

• Wijewickrama, G., Kim, J.-H., Kim, Y.J., Ananthanarayanan, B., Abraham, A. Oh, Y. Kwatia, M., Ackerman, S. and Cho, W. (2006) “Systematic Evaluation of Transcellular Activities of Secretory Phospholipases A₂: HIGH ACTIVITY OF GROUP V PLA₂ TO INDUCE EICOSANOID BIOSYNTHESIS IN NEIGHBORING INFLAMMATORY CELLS,” J. Biol. Chem. 281, 10935-10944

• Bhardwaj, N., Stahelin, R.V., Langlois, R.E., *Cho, W., and *Lu, H. (2006), “Structural Bioinformatics Prediction of Membrane-Binding Proteins” J. Mol Biol. 359, 486-495 (* Co-corresponding authors)

• Cho, W. (2006) “Special Issue: Lipid-binding domains,” Biochim. Biophys. Acta (Preface) 1761, 803-804.

• Muñoz, N.M. Meliton, A.Y. Lambertino, A., Boetticher, E., Learoyd, J., Sultan, F., Zhu, X., Cho, W., and Leff, A.R. (2006) “Transcellular secretion of group V phospholipase A₂ from epithelium induces β-integrin mediated adhesion and synthesis of leukotriene C₄ in eosinophil,” J. Immunol 177, 574-82

• Cho, W. and Stahelin, R. V. (2006) “Membrane binding and subcellular targeting of C2 domains,” Biochim. Biophys. Acta (Review) 1761, 838-849.

• Chaudhari, A., Fialho, A.M., Ratner, D., Gupta, P., Hong, C.S., Kahali, S., Yamada, T., Haldar, K., Cho, W., Chauhan, V.S., Gupta, T.D., and Chakrabarty, A.M. (2006) “Azurin, Plasmodium falciparum Malaria and HIV/AIDS: Inhibition of Parasitic and Viral Growth by Azurin,” Cell Cycle 5:15, 1642-1648

• Mallikaratchy, P. Stahelin, R.V., Zehui Cao, Z., Cho, W., and Tan, W., (2006) “Selection of DNA ligands for protein kinase C-δ” Chem. Comm, 2006, 3229-3231

• Wijewickrama, G.T. Albanese, A., Kim, Y. J., Oh, Y.S., Murray, P.S., Takayanagi, R., Tobe, T., Masuda, S., Murakami, M., Kudo, I., Ucker, D.S., Murray, W., Cho, W., (2006)  “Unique Membrane Interaction Mode of Group IIF Phospholipase A₂” J. Biol. Chem. 281, 32741-32754

• Malkova, S., Stahelin, R.V., Pingali, S.V., Cho, W., and Schlossman, M.L. (2006) “X-ray Reflectivity Studies of p40phox-PX Domains Adsorbed onto Langmuir Monolayers of SOPC/SOPS/PI3P” Biochemistry  45, 13566-13575

• S. Lee, J. Kovacs, R. V. Stahelin, M. L. Cheever, C. Burd, W. Cho and T. G. Kutateladze (2006) “Molecular mechanism of membrane docking by the Vam7p PX domain,” J. Biol. Chem. 281, 37091-37101

• Stahelin, R.V., Karathanassis, D. Bruzik, K.S., Waterfield, M.D., Bravo, J., Williams, R.L., Cho, W., (2006) “Structural and Membrane Binding Analysis of the PX Domain of Phosphoinositide 3-Kinase-C2α,” J. Biol. Chem. 281, 39396-39406.

<2005>

• Cho, W. and Stahelin, R.V. “Membrane-protein interactions in cell signaling and membrane trafficking,” (2005) Ann. Rev. Biophys. Biomol. Struct. 34, 119-151

• Taha, T.A., Kitatani, K., Bielawski, J., Cho, W., Hannun, Y. A., and Obeid, L.M. (2005) “TNF induces the loss of sphingosine kinase-1 by a cathepsin B dependent mechanism,” J. Biol. Chem. 280, 17196-17202

• Subramanian, P., Stahelin, R.V., Szulc, Z., Bielawska, A., Cho, W. and Chalfant, C.E. (2005) “Ceramide-1-phosphate acts as a positive allosteric activator of cytosolic phospholipase A₂ and enhances the interaction of the enzyme with phosphatidylcholine” J. Biol. Chem. 280, 17601-17607

• Stahelin, R.V. Digman, M.A., Medkova, M., Ananthanarayanan, B., Rafter, J.D., Melowic, H.  and Cho, W. (2005) “Diacylglycerol-Induced Membrane Targeting and Activation of Protein Kinase Cε: Mechanistic Differences between PKCδ and ε” J. Biol. Chem. 280, 19784-19793

• Angulo, Y, Gutiérrez, J.M., Soares, A.M., Cho, W., and Lomonte, B. (2005) “Myotoxic and cytolytic activities of dimeric Lys49 phospholipase A₂ homologues are reduced, but not abolished, by a pH-induced dissociation,” Toxicon, 46(3), 291-6

• Cho, W. and Stahelin, R.V. “In vitro and cellular membrane binding mechanisms of membrane targeting domains,” (2005) In “Protein-Lipid Interactions”, Tamm, L. K. Ed., Academic Press, N.Y. pp. 369-401

• Malkova, S., Long, F., Stahelin, R.V. Pingali, S.V., Murray, D., Cho, W., and Schlossman, M. (2005) “Determination of the depth of membrane insertion of C2 domains by X-ray reflectivity measurements” Biophys. J. 89, 1861-1873

• Stahelin, R.V., Wang, J., Blatner, N.R. Rafter, J.D., Murray, D., and Cho, W. (2005) “The origin of C1A-C2 interdomain interactions in protein kinase Cα” J. Biol. Chem. 280, 36452-36463

• Gokhale, N. A. Abraham, A. Digman, M.A., Gratton, E., and Cho, W. (2005) “Phosphoinositide specificity of and mechanism of lipid domain formation by annexin A2-p11 tetramer” J. Biol. Chem. 280, 42831-42840

• Stahelin, R.V., Hwang, J.H., Kim, J.-H., Park, Z.-Y., Johnson, K.R., Obeid, L.M., and Cho, W. (2005) “The mechanism of membrane targeting of human sphingosine kinase 1,” J. Biol. Chem. 280, 43030-43038

<2004>

• Stahelin, R.V. Digman, M.A., Medkova, M. Ananthanarayanan, B., Rafter, J.D., Melowic, H. and Cho, W. (2004) “Mechanisms of diacylglycerol-induced membrane binding and activation of protein kinase Cd” J. Biol. Chem. 279, 29501-29512.

• Blatner, N.R., Stahelin, R.V., Diraviyam, K. Bruzik, K.S., Hawkins, P.T., Hong, W., Murray, D., and Cho, W. (2004) “The Molecular Basis of the Differential Subcellular Localization of FYVE Domains,” J. Biol. Chem. 279, 53818-53827

• Stahelin, R.V., Ananthanarayanan, B., Blatner, N.R., Singh, S., Bruzik, K.S. Murray, D., and Cho, W. (2004) “Mechanism of Membrane Binding of the Phospholipase D1 PX Domain,” J. Biol. Chem. 279, 54918-54926.

<2003>

• Lee, B.-I., Mustafi, D., Cho, W., and Nakagawa, Y. (2003) “Characterization of Calcium Binding Properties of Lithostathine,” J. Biol. Inorg. Chem. 8, 341-347

• Stahelin, R.V. Forslund, R.E., Wink, D.J. and Cho, W. (2003) “Development of a biochemistry laboratory course with a project-oriented goal” Biochemistry and Molecular Biology Education. 31, 106-112

• Stahelin, R.V., Rafter, J.D., Das, S. and Cho, W. (2003) "A Molecular Basis of Differential Subcellular Localization of C2 Domains of Protein Kinase C-α and Group IVa Cytosolic Phospholipase A₂," J. Biol. Chem. 278, 12452-12460

• Stahelin, R.V. Burian, A., Bruzik, K.S., Murray, D. and Cho, W. (2003) “Membrane binding mechanisms of the PX domains of NADPH oxidase p40^phox and p47^phox,” J. Biol. Chem. 278, 14469-14479

• Diraviyam, K., Stahelin, R. V., Cho, W., and Murray, D. (2003) “Computer modeling of the membrane interaction of FYVE domains,” J. Mol. Biol. 328, 721-736

• Liu, Y., Bruzik, K.S., Ananthanarayanan, B., and Cho, W. (2003) “New aspects of formation of 1,2-cyclic phosphate by phospholipase C-d1,” Bioorg. Med. Chem. Lett. 11, 2471-2475

• Cho, W., Digman, M.A., Ananthanarayanan, B. and Stahelin, R.V. (2003) "Bacterial expression and purification of C1 and C2 domains of protein kinase C isoforms" in Methods in Molecular Biology, vol. 233: Protein Kinase C Protocols, Ed., Newton, A.C., K. Humana Press, Totowa, New Jersey,  291-298.

• Das, S., Dixon, J.E. and Cho, W. (2003) “Mechanism of membrane targeting and activation of PTEN,” Proc. Natl. Acad. Sci. USA 100, 7491-7496.

• Stahelin, R.V., Long, F., Murray, D. Peter, B.J., De Camilli, P., McMahon, H.T., and Cho, W. (2003) “Contrasting membrane binding mechanisms of ENTH and ANTH domains,” J. Biol. Chem. 278, 28993-28999

• Muñoz, N.M., Kim, Y.J., Kim, K.-P., Zhu, X., Leff, A.R., and Cho, W (2003) “Group V Phospholipase A₂ Induces Group IVA Phospholipase A₂-Independent Cysteinyl Leukotriene Biosynthesis in Human Eosinophils,” J. Biol. Chem. 278, 38813-38820

• Murakami, M, Das, S., Kim, Y.J., Cho, W., Kudo, I. (2003), “Perinuclear localization of cytosolic phospholipase A2α is crucial but notobligatory for coupling with cyclooxygenases” FEBS Lett 546, 251-256

• Wehbi, H., Feng, J., Kolbeck, J., Ananthanarayanan, B., Cho, W., and Roberts, M. F. (2003) “Investigating the Interfacial Binding of Bacterial Phosphatidylinositol-Specific Phospholipase C” Biochemistry 42, 9374-9382

• Ryu, Y., Oh, Y., Yoon, J., Cho W., Baek, K. (2003) “Molecular characterization of a gene encoding the Drosophila melonogaster phospholipase A₂” Biochim. Biophys. Acta 1628, 206-210

• Das, S., Rafter, J.D., Kim, K.-P., Gigy, S.P., and Cho, W. (2003) “Mechanism of group IVA cytosolic phospholipase A₂ activation by phosphorylation,” J. Biol. Chem. 278, 41431-41442.

• Ananthanarayanan, B., Stahelin, R. V., Digman, M. A., and Cho, W. (2003) “Activation Mechanisms of Protein Kinase C Isoforms Are Determined by the Ligand Affinity and Conformational Flexibility of Their C1 Domains,” J. Biol. Chem. 278, 46886-46894.

<2002>

• Ananthanarayanan, B., Das, S., Rhee, S.G., Murray, D. and Cho, W. (2002) “ Membrane Targeting of C2 Domains of Phospholipase C-d Isoforms” J. Biol. Chem. 277, 3568-3575.

• Beers, S.A., Buckland, A.G., Koduri, R.S. Cho, W., Gelb, M.H., and Wilton, D.C. (2002) “The antibacterial properties of secreted phospholipase A₂: A major physiological role for the IIA enzyme that depends on the very high pI of the enzyme to allow penetration of the bacterial cell wall” J. Biol. Chem. 277, 1788-1793.

• Han, J.M., Kim, J.H., Lee, B.D., Lee, S.D., Kim, Y., Chung, Y.W., Lee, S., Cho, W., Ohba, M., Kuroki, T., Suh, P.-G. and Ryu, S.H. (2002) “Phosphorylation-dependent regulation of Phospholipase D2 by Protein Kinase C in Rat pheochromocytoma  PC12 cells,” J. Biol. Chem. 277, 8290-8297.

• Kim, Y.J., Kim, K.P., Rhee, H. J., Das, S. Rafter, J.D., Oh, Y.S., and Cho, W. (2002) “Internalized Secretory Phospholipase A₂ Acts on the Perinuclear Membranes” J. Biol. Chem. 277, 9358-65.

• Kulkarni, S., Das, S., Funk, C.D., Murray, D., and Cho, W. (2002) “A molecular basis of specific subcellular localization of the C2-like domain of 5-lipoxygenase” J. Biol. Chem. 277, 13167-13174.

• Gesquire, L., Cho, W., and Subbaiah, P.V. (2002) “Roles of group IIa and group V secretory phospholipases A₂ in the metabolism of lipoproteins. Substrate specificities of the enzymes, and the regulation of their activities by sphingomyelin,” Biochemistry 41, 4911-4920.

• Muñoz, N.M., Boetticher, E., Sperling, A.I., Kim, K.P., Meliton, A., Lambertino, A., Cho, W., and Leff, A.R. (2002) “Deveolpment of highly sensitive sandwich enzyme-linked immunosorbent assay (sELISA) for group V phospholipase A₂ (gVPLA₂): determination of gVPLA₂ in human epithelial cells and eosinophils” J. Immunol. Methods, 262, 41-51.

• Das, S. and Cho, W. (2002) “Roles of Catalytic Domain Residues in Interfacial Binding and Activation of Group IV Cytosolic Phospholipase A₂,” J. Biol. Chem. 277, 23838–23846.

• Stahelin, R. V. Long, F., Diraviyam, K., Bruzik, K.S., Murray, D. and Cho, W. (2002) “Phosphatidylinositol-3-Phosphate Induces the Membrane Penetration of the FYVE Domains of Vps27p and Hrs” J. Biol. Chem. 277, 26379-26388.

• Kim, Y.J., Kim, K.P., Han, S.K., Munoz, N.M., Zhu, X., Sano, H, Leff, A.R., and Cho, W. (2002) “Group V Phospholipase A₂ Induces Leukotriene Biosynthesis in Human Neutrophils through the Activation of Group IVA Phospholipase A₂" J. Biol. Chem. 277, 36479-36488

• Karathanassis, D., Stahelin, R.V., Bravo, J., Perisic, O., Pacold, C. M., Cho, W., Williams, R.L. (2002) “Binding of the PX domain of p47^phox to phosphatidylinositol 3,4-bisphosphate and phosphatidic acid is masked by an intramolecular interaction”  EMBO J. 21, 5057-5068

<2001>

• Bittova, L., Stahelin, R. V. and Cho, W. (2001) "Roles of Ionic Residues of the C1 Domain in Protein Kinase C-α Activation and the Origin of Phosphatidylserine Specificity," J. Biol. Chem. 276, 4218-4226.

• Myou, S., Sano, H., Fujimura, M., Zhu, X., Kurashima, K., Kita, T., Nakao, S., Nonomura, A., Takanobu, S., Kim, K.P., Muñoz, N. M., Cho, W., and Leff, A. R. (2001) “Inhibition of cytosolic PLA₂ and lysophospholipid synthesis blocks antigen-induced eosinophil migration and airway hyper responsiveness,” Nature Immunol 2, 145-149

• Kim, K.-P., Rafter, J. D., Bittova, L., Han, S.-K., Snitko, Y., Muñoz, N.M., Leff, A. R., and  Cho, W (2001) “Mechanism of Human Group V Phospholipase A₂-Induced Leukotriene Biosynthesis in Human Neutrophils: A Potential Role of Heparan Sulfate Binding in PLA₂ Internalization and Degradation,” J. Biol. Chem. 276, 11126–11134.

• Stahelin, R. V. and Cho, W. (2001) “Roles of ionic, aliphatic, and aromatic residues in membrane-protein interactions: A surface plasmon resonance study on phospholipases A₂,” Biochemistry  40, 4672-4678

• Cho, W. (2001) “Membrane targeting by C1 and C2 domains,” J. Biol. Chem. (minireview) 276, 32407-32410.

• Cho, W., Bittova, L., and Stahelin, R. V. (2001) “In vitro Membrane Binding Assays for Peripheral Proteins” Anal. Biochem. (review article)  296, 153-161.

• Zhu, X., Sano, H., Kim, K.P., Sano, A., Boetticher, E., Muñoz, N.M., Cho, W., and Leff, A.R. (2001) “Role of MAP Kinase-Mediated Cytosolic Phospholipase A₂ Activation in Arachidonic Acid Metabolism in Human Eosinophils”  J. Immunol 167, 461-468

• Stahelin, R. V. and Cho, W. (2001) “Roles of Calcium Ions in Membrane Binding and Subcellular Targeting of C2 Domains”  Biochem. J. 359, 679-685

<2000>

• Muñoz, N. M., Kim, K., Han, S.-K., Boetticher, E. Sperling, A. I. Sano, H.  Zhu, X. Cho, W., and Leff, A. R. (2000) “Characterization of Monoclonal Antibodies Specific for 14 kDa human group V Secretory Phospholipase A₂,” Hybridoma  19, 171-176

• Kim, K., Han, S.-K., Hong, M., and Cho, W (2000) “Molecular Basis for Phosphatidylcholine Preference of Human Group V Phospholipase A₂,” Biochem. J. 348, 643-647

• Bitto, E., Li, M., Tikhonov, A., Schlossman, M. L., Cho, W. (2000) “Mechanism of vesicle aggregation by annexin I,” Biochemistry  39, 13469-13477

• Cho, W. (2000) “Structure and function of group V phospholipase A₂,” Biochim. Biophys. Acta (review article) 1488, 48-58.

<1990s>

• Lomonte, B. Angulo, Y. Rufini, S. Cho, W. Giglio, J.R. Ohno, M. Daniele, J.J, Geoghegan, P. and Gutiérrez, J.M. (1999) "Comparative study of the cytolytic activity of myotoxic phospholipases A₂ on mouse endothelial (tEnd) and skeletal muscle (C2C12) cells in vitro" Toxicon 37(1):145-58

• Cho, W., Han, S.-K., Lee, B.-I., Snitko, Y. and Dua, R. (1999)  "Purification and Assay of Mammalian Group I and Group IIa Secretory Phospholipase A₂" in Methods in Molecular Biology, vol. 109: Lipase and Phospholipase Protocols, Eds, Doolittle, M.H. and Reue, K. Humana Press, Totowa, New Jersey  pp 31-38

• Cho, W. and Shen, Z. (1999) "Efficient Immobilization of Phospholipase A₂" in Methods in Molecular Biology, vol. 109: Lipase and Phospholipase Protocols, Eds, Doolittle, M.H. and Reue, K. Humana Press, Totowa, New Jersey pp. 303-307

• Cho, W., Wu, S.-K., Yoon, E.T. and Lichtenbergova, L. (1999) "Fluorometric Phospholipase Assays Based on Polymerized Liposome Substrates" in  Methods in Molecular Biology, vol. 109: Lipase and Phospholipase Protocols, Eds, Doolittle, M.H. and Reue, K. Humana Press, Totowa, New Jersey  pp.7-17

• Bittova, L., Sumandea, P.M. and Cho, W. (1999) “A Structure-Function Study of C2 Domain of Cytosolic Phospholipase A₂: Identification of essential calcium ligands and hydrophobic membrane binding residues” J. Biol. Chem. 274, 9665-9672

• Han, S.-K., Kim, K.P., Koduri, R., Bittova, L., Munoz, N.M., Leff, A. R., Wilton, D.C., Gelb, M.H., and Cho, W. (1999) “Role of Trp³¹ in high membrane binding and pro-inflammatory activity of human group V phospholipase A₂” J. Biol. Chem. 274, 11881-11888

• Wilson, H.A., Waldrip, J.B., Nielson, K.H., Judd, A.M., Han, S.-K., Cho, W., Sims, P.J., and  Bell, J.D. (1999) “Mechanisms by which elevated intracellular calcium induces S49 cell membranes to become susceptible to the action of secretory phospholipase A₂” J. Biol. Chem. 274, 11494-11504

• Medkova, M. and Cho, W. (1999) "Interplay of the C1 and C2 Domains of Protein Kinase C-α in Its Membrane Binding and Activation" J. Biol. Chem 274, 19852-19861

• Snitko, Y., Han, S.-K. and Cho, W. (1999) "Interfacial and Substrate Binding of Human Pancreatic Phospholipase A₂: A Comparison among Mammalian Pancreatic Phospholipases A₂" Biochemistry 38, 7803-7810

• Lee, B.-I., Dua, R. and Cho, W. (1999) "A Structural Determinant of the Unique Interfacial Binding Mode of Bovine Pancreatic Phospholipase A₂" Biochemistry 38, 7811-7818

• Gelb, M.H., Cho, W. and Wilton, D.C. (1999) “Interfacial Binding of Secreted Phospholipases A₂: More Than Electrostatics and a Major Role for Tryptophan” Current Opinions in Structural Biology 9, 428-432

• Zhu, X., Muñoz, N.M., Kim, K.-P., Sano, H., Cho, W, and Leff, A. R., (1999) “Cytosolic Phospholipase A₂ Activation is Essential for β₁ and β₂ Integrin-Dependent Adhesion to Human Eosinophils,” J. Immunol 163, 3423-3429

• Bitto, E. and Cho, W. (1999) “A Structural Determinant of the Vesicle Aggregation Activity of Annexin I," Biochemistry  38, 14094-14100

• Sumandea, M., Das, S., Sumandea, C. and Cho, W. (1999) “Roles of Aromatic Residues in High Interfacial Activity of Naja naja atra Phospholipase A₂," Biochemistry 38, 16290-16297

• Han, S.-K., Yoon, E.T. and Cho, W.  (1998) "Functional Expression and Characterization of Human Secretory Class V Phospholipase A₂" Biochem. J. (Communication) 331, 353-357

• Medkova, M. and Cho, W.  (1998) "Differential membrane-binding and activation mechanisms of Protein Kinase C-α and -ε" Biochemistry 37, 4892-4900

• Ghosh, A.K., Kinkaid, J.F., Cho, W., Walters, D.E., Krishnan, K., Hussain, K.A., Koo, Y., Cho, H., Rudall, C., Holland, L., Buthod (1998) "Potent HIV Protease Inhibitors Incorporating High Affinity P2-Ligands and (R)-(Hydroxyethylamino)-Sulfonamide Isostere" Bioorg. Med. Chem. Lett. 8, 687-690

• Ghosh, A. K., K. Krishnan, D. E. Walters, W. Cho, Y. Koo, H. Cho, L. Holland, J. Buthod (1998) "Structure Based Design: Novel Spirocyclic Ethers as Nonpeptidal P2-Ligands for HIV Protease Inhibitors" Bioorg. Med. Chem. Lett. 8, 979-982

• Medkova, M. and Cho, W. (1998) "Mutagenesis of the C2 Domain of Protein Kinase C-α: Differential Roles of Ca²⁺ Ligands and Membrane Binding Residues" J. Biol. Chem. 273, 17544-17552

• Bitto, E. and Cho, W. (1998) "Roles of Individual Domains of Annexin I in Its Vesicle Binding and Vesicle Aggregation: A Comprehensive Mutagenesis Study" Biochemistry 37, 10231-10237

• Lichtenbergova, L., Yoon, E. T. and Cho, W. (1998)  "Membrane Penetration of Cytosolic Phospholipase A₂ is Necessary for Its Interfacial Catalysis and Arachidonate Specificity" Biochemistry 37, 14128-14136

• Lin, Y. Ghomashchi, F., Nielsen, R., Snitko, Y., Yu, B.-Z., Han, S.-K., Cho, W., Wilton, D. C., Jain, M.K., Robinson, B.H. and Gelb, M. H.  (1998) "Binding of bee venom and human group IIa phospholipases A₂ to membranes: a minor role for electrostatics." Biochem Soc Trans. 26, 341-5

• Koduri, R., Baker, S.F., Snitko, Y., Han, S.-K., Cho, W., Wilton, D. C. and Gelb, M. H. (1998)  "Action of Human Group IIa Secreted Phospholipase A₂ on Cell Membranes: Vesicle but not Heparanoid Binding Determines Rate of Fatty Acid Release" J. Biol. Chem. 273, 32142-32153

• Snitko, Y., Yoon, E. T. and Cho, W. (1997)  "High Specificity of Human Secretory Class II Phospholipase A₂ for Phosphatidic Acid" Biochem. J.  321, 737-741

• Han, S.-K., Yoon, E. T., Scott, D.L., Sigler, P.B. and Cho, W. (1997)  "Structural Aspects of Interfacial Adsorption: A Crystallographic and Site-directed Mutagenesis Study of the Phospholipase A₂ from the Venom of Agkistrodon piscivorus piscivorus" J. Biol. Chem. 272, 3573-3582

• Han, S.-K., Lee, B.-I., and Cho, W. (1997) "The Bacterial Expression and Kinetic Characterization of Human Pancreatic Phospholipase A₂" Biochim. Biophys. Acta 1346, 185-192

• Kim, Y., Lichtenbergova, L., Snitko, Y., and Cho, W. (1997) "A Phospholipase A₂ Kinetic and Binding Assay Using Phospholipid-Coated Hydrophobic Beads" Anal. Biochem.  250, 109-116

• Snitko, Y., Koduri, R., Han, S.-K., Othman, R., Baker, S.F., Molini, B. J., Wilton, D. C., Gelb, M. H., and Cho, W. (1997)  "Mapping the Interfacial Binding Surface of Human Secretory Class II Phospholipase A₂" Biochemistry 36, 14325-14333

• Mukhopadhyay, S. and Cho, W.  (1996) “Interactions of Annexin V with Phospholipid Monolayers“ Biochim. Biophys. Acta 1276, 58-62

• Lee, B.-I., Yoon, E.T. and Cho, W. (1996)  "Roles of Surface Hydrophobic Residues in the Interfacial Binding of Bovine Pancreatic Phospholipase A₂" Biochemistry  35, 4231-4240

• Dua, R., Wu, S.-K., and Cho, W.  (1995)  "A Structure-Function Study of Bovine Pancreatic Phospholipase A₂ Using Polymerized Mixed Liposomes" J. Biol. Chem. 270,  263-268

• Shen, Z. and Cho, W.  (1995) "Highly Efficient Site-Specific Immobilization of Phospholipases A₂" J. Lipid Res. 36,  1147-1151

• Shen, Z. and Cho, W.  (1995) "Membrane Leakage Induced by Synergetic Action of Lys-49 and Asp-49 Agkistrodon Piscivorus Piscivorus Phospholipases A₂: Implications in Their Pharmacological Activities" Int. J. Biochem. Cell Biol.  27/10, 1009-1013

• Dua, R. and Cho, W.  (1994) "Inhibition of Human Secretory Class II Phospholipase A₂ by Heparin" Eur. J. Biochem. 221, 481-490

• Wu, S.-K. and Cho, W.  (1994) "A continuous Fluorometric Assay for Phospholipases Using Polymerized Mixed Liposomes"  Anal. Biochem.  221, 152-159

• Shen, Z., Wu, S.-K. and Cho, W. (1994) "Effects of Specific Fatty-Acid Acylation of Phospholipase A₂ on Its Interfacial Binding and Catalysis"  Biochemistry 33,  11598-11607

• Wu, S.-K. and Cho, W.  (1993)  "Use of Polymerized Liposomes to Study Interactions of Phospholipase A₂ with Biological Membranes" Biochemistry 32, 13902-13908

• Cho, W. and Kézdy, F. J. (1991)  "Chromogenic Phospholipase A₂ Substrates and Assays" Methods Enzymol.  197,  75-78

• Cho, W., Markowitz, M.A., and Kézdy, F.J. (1988)  "A New Class of Phospholipase A₂ Substrates: Kinetics of the Phospholipase A₂-Catalyzed Hydrolysis of 3-Acyloxy-4-Nitrobenzoic Acids" J. Am. Chem. Soc. 110,  5166-5171

• Cho, W., Tomasseli, A.G., Heinrikson, R.L., and Kézdy, F.J. (1988)  "The Chemical Basis for Interfacial Activation of Monomeric Phospholipase A₂" J. Biol. Chem. 263,  11237-11241

• Suh, J., Cho, W., and Chung, S. (1985) "Carboxypeptidase A-Catalyzed Hydrolysis of α-(Acylamino)-cinnamoyl Derivatives of L-β-Phenyllactate and L-Phenylalanate: Evidence for Acyl-Enzyme Intermediates" J. Am. Chem. Soc. 107,  4530-4535

• Maraganore, J.M., Merutka, G., Cho, W., Welches, W., Kézdy, F.J., and Heinrikson, R.L. (1984) "A New Class of Phospholipase A₂ with Lysine in Place of Aspartate 49: Functional Consequences of Calcium and Substrate Binding" J. Biol. Chem. 259,  13839-13843