Facilities

This sensitive multi-photon microscope with two separate tunable laser sources located in an independently temperature-controlled room allows various state-of-art fluorescence measurements, including all in situ quantitative lipid imaging in living cells, tissues and animals. The microscope is also equipped with an automated microinjector and a perfusion chamber.

A three-channel total internal reflection fluorescence (TIRF) microscope equipped with three Andor iXon Ultra EM-CCD cameras in an environment-controlled, clean room-quality room allows single molecule tracking of three different molecules. This system is mainly used to monitor dynamic and transient protein-protein interactions and lipid-protein interactions in live cells

This brand new state-of-art microscopy with high speed and sensitivity will allow us to quantitatively monitor spatiotemporal dynamics and interactions of multiple protein and lipid species in live cells. This will also allow us to screen small molecules that modulate membrane binding of pharmacologically important proteins in live cells.

This sensitive instrument serves as
our main tool for quantitatively measuring lipid-protein
and protein-protein interactions in vitro.

It is a powerful tool for accurately
determining thermodynamic parameters (Kd, free energy of binding, etc) for molecular interactions, including
lipid-protein and protein-protein interactions.

This sensitive and fast multi-mode (fluorescence
intensity, fluorescence polarization, time resolved
fluorescence, UV-Vis absorbance, and
luminescence detection) reader is used for
our high-throughput screening of small
molecules that modulate membrane
binding of pharmacologically important proteins.

This state-of-art spectrofluorometer
allows fluorescence
intensity, anisotropy, life-time
measurements.
It is used for in vitro molecular
interaction analysis.

Our conference room is also our
social activity and lunch room.